Aldesulfone sodium

Aldesulfone sodium

Systematic (IUPAC) name
[4-[4-(sulfinomethylamino) phenyl] sulfonylphenyl] aminomethanesulfinic acid
Clinical data
Pregnancy cat.	?
Legal status	?
Routes	Oral
Pharmacokinetic data
Protein binding	69%
Metabolism	Hepatic
Half-life	3 to 8 hours
Identifiers
CAS number	144-75-2^Y
ATC code	J04BA03
PubChem	CID 8954
DrugBank	APRD00704
ChemSpider	8610^Y
UNII	57OWB0Q221^Y
KEGG	D02521^Y
ChEMBL	CHEMBL1200580^N
Chemical data
Formula	C₁₄H₁₆N₂O₆S₃
Mol. mass	404.485 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C14H16N2O6S3.2Na/c17-23(18)9-15-11-1-5-13(6-2-11)25(21,22)14-7-3-12(4-8-14)16-10-24(19)20;;/h1-8,15-16H,9-10H2,(H,17,18)(H,19,20);;/q;2*+1/p-2^Y Key:AZBNFLZFSZDPQF-UHFFFAOYSA-L^Y
N(what is this?) (verify)

Aldesulfone sodium (or sulfoxone) is an antibiotic used in the treatment of leprosy.

Sulfoxone sodium was introduced in Japan in 1948.^[1]

References

^ "[A 50-year history of new drugs in Japan: the developments of antileprosy drugs and their epidemiological aspects]". Yakushigaku Zasshi 37 (1): 76–83. 2002. PMID 12412600.

Rifamycins/ RNA polymerase inhibitor	Rifampicin^# • Rifabutin • Rifapentine

Antifolates/DSI	Dapsone^# • Acedapsone • Aldesulfone sodium

ASA	4-Aminosalicylic acid^# (Calcium aminosalicylate, Sodium aminosalicylate)

Aminoglycosides	Amikacin^# • Capreomycin^# • Kanamycin^# • Streptomycin^#

Oxazolidone	Linezolid

Peptidoglycan layer	Alanine analogue: Cycloserine^#

Arabinogalactan layer	Ethylenediamine/arabinosyltransferase inhibitor: Ethambutol^# SQ109^†

Mycolic acid layer	Hydrazides/mycolic acid synth. inhibition: Isoniazid^# Thiocarbamides: Ethionamide^# • Prothionamide • Thiocarlide

Other/unknown

phenazine (Clofazimine)^# • pyrazine (Pyrazinamide^#, Morinamide) • isoxazole (Terizidone) • R207910/TMC207^†

Combinations

bact (clas)

gr+f/gr+a(t)/gr-p(c)/gr-o

drug(J1p, w, n, m, vacc)

Antifolates
(inhibits
purine metabolism,
thereby inhibiting
DNA and RNA synthesis)

Short- acting	Sulfaisodimidine • Sulfamethizole • Sulfadimidine • Sulfapyridine • Sulfafurazole • Sulfanilamide (Prontosil) • Sulfathiazole • Sulfathiourea

Intermediate- acting	Sulfamethoxazole • Sulfadiazine^# • Sulfamoxole

Long- acting	Sulfadimethoxine • Sulfalene • Sulfametomidine • Sulfametoxydiazine • Sulfamethoxypyridazine • Sulfaperin • Sulfamerazine • Sulfaphenazole • Sulfamazone

Other/ungrouped

Combinations

2nd g.	Ciprofloxacin^# • Enoxacin^‡ • Fleroxacin^‡ • Lomefloxacin • Nadifloxacin • Ofloxacin • Norfloxacin • Pefloxacin • Rufloxacin

3rd g.	Balofloxacin • Grepafloxacin^‡ • Levofloxacin • Pazufloxacin • Sparfloxacin^‡ • Temafloxacin^‡ • Tosufloxacin

4th g.	Besifloxacin • Clinafloxacin^† • Garenoxacin • Gemifloxacin • Moxifloxacin • Gatifloxacin^‡ • Sitafloxacin • Trovafloxacin^‡/Alatrofloxacin^‡ • Prulifloxacin

Vet.	Danofloxacin • Difloxacin • Enrofloxacin • Ibafloxacin • Marbofloxacin • Orbifloxacin • Pradofloxacin • Sarafloxacin

Related (DG)	Aminocoumarins: Novobiocin

Nitro- imidazole derivatives	Metronidazole^# • Tinidazole • Ornidazole

Nitrofuran derivatives	Nitrofurantoin^# • Furazolidone^‡ • Nifurtoinol

RNA synthesis

Rifamycins/ RNA polymerase	Rifampicin • Rifabutin • Rifapentine • Rifaximin

bact (clas)

gr+f/gr+a(t)/gr-p(c)/gr-o

drug(J1p, w, n, m, vacc)